Breakout Ventures, a San Francisco-based seed-stage venture firm that funds what it calls creative biosciences startups, has closed the second fund in its five-year history with $112.5 million in capital commitments.

Both of its funds, including a $60 million debut effort that we wrote about in 2017, are backed by Dolby Family Ventures, the Thiel Foundation, GRIDS Capital, S Cubed Capital, Chris and Crystal Sacca, Tony Fadell, and Zack Bogue and Matt Ocko of DCVC. The new fund also pulled in new institutional LPs, including Cortes Capital and Cupola Funds managed by AMG National Trust.

The outfit is notable for a variety of reasons (beyond its high-wattage backers), starting with its two managing partners, who have long focused on startups at the intersection of biology and technology.

Lindy Fishburne, a management consultant earlier in her career, spent more than a decade as the executive director of the Thiel Foundation, which gave out grants to deep science startups until it became obvious to Fishburne that it was time to start writing venture checks instead.

Julia Moore was meanwhile an associate director at Stanford University before joining the Thiel Foundation as a portfolio director and joining forces with Fishburne afterward at Breakout Ventures. (Moore was promoted to managing partner earlier this year; the Thiel Foundation’s model as been retired as the two build out the Breakout Ventures footprint.)

Put another way, though a small but growing number of outfits has emerged more recently to focus on deep tech, Fishburne and Moore have been at this for a while.

Of course, the bets the two are making were as critical to the fundraising process. While Breakout Ventures has one exit to date — it was among the first investors in Cortexyme, a now publicly traded company that’s developing therapies for Alzheimer’s disease (and encountered a related setback in October) — Breakout Ventures’ young portfolio has a number of highly valued startups.

Among these is Modern Meadow, a company known mostly for its lab-grown leather and that closed on $130 million in Series C funding back in April (at an undisclosed valuation). Breakout Ventures also wrote one of the first checks to Cytovale, a San Francisco-based company that has gone on to raise $50 million and is currently in the final stages of clinical trials of a new test for sepsis that generates results in less than 10 minutes. (Sepsis is the leading cause of death in hospitals, notes Fishburne.)

A third company from that first fund is Checkerspot, a company using synthetic biology and chemistry to produce novel bio-derived oils. Like Cytovale, it has now raised $50 million altogether, including from Viking Global Investors.

Altogether, says the two, their portfolio companies have gone on to raise more than $1 billion in follow-on capital and grants, and they expect the pace to pick up quickly from here, fueled in part, strangely, by the coronavirus pandemic. Asked about the effect on Breakout’s work by the rapid-fire development of vaccines to treat Covid-19, both investors say the impact was both abrupt and lasting.

“It’s been gas on the fire,” says Fishburne. “For the world to see how central science is and its capacity to now be able to move so quickly and be so responsive and driven by the tools of scale that are now available, that has [created an] enormous on-ramp for our companies and the places that we play.”

She points, as one example, to a portfolio company called Phylagen, a San-Francisco based biotech company that combines microbial genomics and data analytics to solve complex problems like pandemic management and supply chain verification.

“They’re using what we think of as traditional biological tools to basically monitor and manage the indoor microbiome and environments of several large tech companies so that they can say to employees to customers, ‘This environment is safe, please come back to work.’”

Moore underscores the same point. “What we saw with Moderna and what we’re seeing at the board level is that [companies’] ability to code a vaccine over a weekend permanently changed the pace of innovation in biosciences. The pace at which we see our companies monitoring timelines is moving [faster] because they have more actionable information and can iterate on that information at a speed we’ve never seen before.”

In the meantime, Breakout is also moving quickly, it seems. Already, the firm has invested in three companies with its new fund, including Parthenon Therapeutics, a two-year-old, Cambridge, Ma.-based biotech that’s developing anti-cancer therapies and which just last week announced $65 million in Series A funding.

Parthenon looks like a traditional therapeutics company, but as Moore tells it, it’s still a fit for Breakout Ventures because it’s “doing a lot of really interesting biomarker work. They’re working with a novel hypothesis. They have an interdisciplinary team that can do multiple different modalities, and so Pfizer and Northpond Ventures led [the investment]. Meanwhile, we’re really more focused on how do we look at the biomarker work and think differently about where to go for partnerships that may be nontraditional. We’re the ones asking: how do you move faster in looking at pipeline with pathology and AI?”

Pictured above: the Breakout Ventures team, with Moore and Fishburne pictured at top, left to right.